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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1898 1
1907 1
1912 1
1915 1
1918 1
1920 1
1924 1
1929 1
1944 1
1946 2
1949 1
1952 2
1953 1
1955 1
1956 1
1960 1
1961 2
1963 1
1964 1
1965 1
1966 5
1967 2
1968 8
1969 6
1970 7
1971 6
1972 5
1973 5
1974 7
1975 43
1976 36
1977 54
1978 51
1979 51
1980 61
1981 48
1982 41
1983 51
1984 73
1985 41
1986 46
1987 58
1988 57
1989 95
1990 82
1991 91
1992 73
1993 85
1994 103
1995 110
1996 113
1997 156
1998 133
1999 186
2000 216
2001 253
2002 324
2003 385
2004 488
2005 582
2006 678
2007 815
2008 969
2009 1127
2010 1359
2011 1492
2012 1702
2013 1852
2014 2121
2015 2336
2016 2434
2017 2737
2018 3036
2019 3342
2020 3440
2021 3514
2022 3597
2023 3494
2024 1347

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40,232 results

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Page 1
Consistency of efficacy results across various clinical measures and statistical methods in the lecanemab phase 2 trial of early Alzheimer's disease.
Dhadda S, Kanekiyo M, Li D, Swanson CJ, Irizarry M, Berry S, Kramer LD, Berry DA. Dhadda S, et al. Alzheimers Res Ther. 2022 Dec 9;14(1):182. doi: 10.1186/s13195-022-01129-x. Alzheimers Res Ther. 2022. PMID: 36482412 Free PMC article. Clinical Trial.
Herein, we describe the results of sensitivity analyses evaluating the consistency of the lecanemab efficacy results in Study 201 at the identified dose, the ED90, across multiple statistical methods and multiple endpoints over the duration of the study. METHODS: Th …
Herein, we describe the results of sensitivity analyses evaluating the consistency of the lecanemab efficacy results in Study 201 at the ide …
A tutorial on pilot studies: the what, why and how.
Thabane L, Ma J, Chu R, Cheng J, Ismaila A, Rios LP, Robson R, Thabane M, Giangregorio L, Goldsmith CH. Thabane L, et al. BMC Med Res Methodol. 2010 Jan 6;10:1. doi: 10.1186/1471-2288-10-1. BMC Med Res Methodol. 2010. PMID: 20053272 Free PMC article.
The objective of this paper is to provide a detailed examination of the key aspects of pilot studies for phase III trials including: 1) the general reasons for conducting a pilot study; 2) the relationships between pilot studies, proof-of-concept studies, and adaptive desi …
The objective of this paper is to provide a detailed examination of the key aspects of pilot studies for phase III trials including: 1) the …
Robust meta-analytic-predictive priors in clinical trials with historical control information.
Schmidli H, Gsteiger S, Roychoudhury S, O'Hagan A, Spiegelhalter D, Neuenschwander B. Schmidli H, et al. Biometrics. 2014 Dec;70(4):1023-32. doi: 10.1111/biom.12242. Epub 2014 Oct 29. Biometrics. 2014. PMID: 25355546
Both frequentist operating characteristics and posterior summaries for various data scenarios show that these designs have desirable properties. We illustrate the methodology for a phase II proof-of-concept trial with historical controls from four studies. ...
Both frequentist operating characteristics and posterior summaries for various data scenarios show that these designs have desirable propert …
Opportunities and pitfalls in clinical proof-of-concept: principles and examples.
Chen C. Chen C. Drug Discov Today. 2018 Apr;23(4):776-787. doi: 10.1016/j.drudis.2018.01.045. Epub 2018 Feb 3. Drug Discov Today. 2018. PMID: 29406264 Review.
Clinical proof-of-concept trials crucially inform major resource deployment decisions. ...
Clinical proof-of-concept trials crucially inform major resource deployment decisions. ...
Office-Based Stapes Surgery.
Voizard B, Maniakas A, Saliba I. Voizard B, et al. Otolaryngol Head Neck Surg. 2019 Dec;161(6):1018-1026. doi: 10.1177/0194599819877652. Epub 2019 Oct 1. Otolaryngol Head Neck Surg. 2019. PMID: 31570044
OBJECTIVE: The objective of this study was to provide a proof of concept and to assess the success and safety of stapes surgery for otosclerosis under local anesthesia in an office-based setting (OBS) as compared with a hospital operating room setting (ORS). ...SETTING: We …
OBJECTIVE: The objective of this study was to provide a proof of concept and to assess the success and safety of stapes surgery for o …
Radiofrequency Ablation for the Management of Pain of Spinal Origin in Orthopedics.
Rodriguez-Merchan EC, Delgado-Martinez AD, De Andres-Ares J. Rodriguez-Merchan EC, et al. Arch Bone Jt Surg. 2023;11(11):666-671. doi: 10.22038/ABJS.2023.71327.3333. Arch Bone Jt Surg. 2023. PMID: 38058968 Free PMC article. Review.
RF seems to be a helpful procedure for relieving chronic pain syndromes; despite this, definite proof of the procedure's effectiveness is still needed. RF is an encouraging procedure for treating chronic spinal pain, especially when other pro …
RF seems to be a helpful procedure for relieving chronic pain syndromes; despite this, definite proof of the procedure' …
Epidemiological study designs.
Diomidus M. Diomidus M. Stud Health Technol Inform. 2002;65:126-35. Stud Health Technol Inform. 2002. PMID: 15460223 Review.
Well-designed observational studies can provide useful insights on disease causation, even though they do not constitute proof of causes. Cohort studies are best for studying the natural progression of disease or risk factors for disease; case-control studies are much quic …
Well-designed observational studies can provide useful insights on disease causation, even though they do not constitute proof of cau …
Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations.
Gewandter JS, Dworkin RH, Turk DC, McDermott MP, Baron R, Gastonguay MR, Gilron I, Katz NP, Mehta C, Raja SN, Senn S, Taylor C, Cowan P, Desjardins P, Dimitrova R, Dionne R, Farrar JT, Hewitt DJ, Iyengar S, Jay GW, Kalso E, Kerns RD, Leff R, Leong M, Petersen KL, Ravina BM, Rauschkolb C, Rice ASC, Rowbotham MC, Sampaio C, Sindrup SH, Stauffer JW, Steigerwald I, Stewart J, Tobias J, Treede RD, Wallace M, White RE. Gewandter JS, et al. Pain. 2014 Sep;155(9):1683-1695. doi: 10.1016/j.pain.2014.05.025. Epub 2014 May 24. Pain. 2014. PMID: 24865794 Free PMC article. Review.
Proof-of-concept (POC) clinical trials play an important role in developing novel treatments and determining whether existing treatments may be efficacious in broader populations of patients. ...
Proof-of-concept (POC) clinical trials play an important role in developing novel treatments and determining whether existing treatme …
The Prospective Studies of Atherosclerosis (Proof-ATHERO) Consortium: Design and Rationale.
Tschiderer L, Seekircher L, Klingenschmid G, Izzo R, Baldassarre D, Iglseder B, Calabresi L, Liu J, Price JF, Bae JH, Brouwers FP, de Groot E, Schmidt C, Bergström G, Aşçi G, Gresele P, Okazaki S, Kapellas K, Landecho MF, Sattar N, Agewall S, Zou ZY, Byrne CD, Nanayakkara PWB, Papagianni A, Witham MD, Bernal E, Ekart R, van Agtmael MA, Neves MF, Sato E, Ezhov M, Walters M, Olsen MH, Stolić R, Zozulińska-Ziółkiewicz DA, Hanefeld M, Staub D, Nagai M, Nieuwkerk PT, Huisman MV, Kato A, Honda H, Parraga G, Magliano D, Gabriel R, Rundek T, Espeland MA, Kiechl S, Willeit J, Lind L, Empana JP, Lonn E, Tuomainen TP, Catapano A, Chien KL, Sander D, Kavousi M, Beulens JWJ, Bots ML, Sweeting MJ, Lorenz MW, Willeit P; Proof-ATHERO Study Group. Tschiderer L, et al. Gerontology. 2020;66(5):447-459. doi: 10.1159/000508498. Epub 2020 Jul 1. Gerontology. 2020. PMID: 32610336 Free article.
Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHERO central database. Statistical analyses are being conducted according to pre-defined analysis plans and use established methods for …
Contributing studies undergo a detailed data cleaning and harmonisation procedure before being incorporated in the Proof-ATHER …
Proof of efficacy trials: cross-over versus parallel-group.
Richens A. Richens A. Epilepsy Res. 2001 May;45(1-3):43-7; discussion 49-51. doi: 10.1016/s0920-1211(01)00214-5. Epilepsy Res. 2001. PMID: 11461793 Review.
As a result, the financial cost is smaller and fewer patients are exposed to the new agent, perhaps with ethical arguments in favour of this type of design in proof-of-efficacy trials. Within-patient analysis also makes the detection of drug interactions more robust. ...Pa …
As a result, the financial cost is smaller and fewer patients are exposed to the new agent, perhaps with ethical arguments in favour of this …
40,232 results
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